Athens State University has five Off-Campus Centers located in various areas of North Alabama with the goal of expanding the opportunities for traditional and non-traditional students to pursue degrees or certifications at locations where education might otherwise be limited. Each Center is staffed with a Center Manager to provide student support services in admissions, registration, academic advising, financial aid, and more. The Off-Campus Centers are broken down into two organizational models: University Centers and Distance Learning Centers.

Athens State University has centers located on the campus of Wallace State Community College-Hanceville, Northeast Alabama Community College, and Redstone Arsenal. These centers serve as recruiting and advising facilities as well as offer onsite and distance learning classes.

Athens State University has centers located on the campus of Snead State Community College and Northwest Shoals Community College. These centers serve as recruiting and advising facilities and offer only distance learning classes.